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            Recombinant Rat CDNF重組大鼠腦多巴胺神經(jīng)營養(yǎng)因子
             
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            產(chǎn)品說明書
                  
            FAQ
                  
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            已發(fā)表文獻(xiàn)
                  
             
            Cerebral dopamine neurotrophic factor (CDNF), also known as ARMET-like protein 1, is a protein encoded by the CDNF gene and it is widely expressed in neuronal and non-neuronal tissues. The cerebral dopamine neurotrophic factor (CDNF) also is a novel neurotrophic factor with strong trophic activity on dopaminergic neurons comparable to that of glial cell line-derived neurotrophic factor (GDNF). By research, CDNF prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons and it might be beneficial for the treatment of parkinson's disease. The human CDNF cDNA encodes a 187 aa protein with a 24 aa signal sequence and a 163 mature sequence. Mature human CDNF shares 80%, 84%, 90% and 92% aa identity with mouse, rat, equine and bovine CDNF, respectively. Although CDNF mRNA and protein are expressed in pre- and post-natal mouse brain, they are most abundant in adult heart, skeletal muscle and testis. Transcripts within the postnatal mouse brain are concentrated in the hippocampus, thalamus, corpus callosum and optic nerve. 
            


             
            


            Product Properties
            


            
	
		
            
			
			
            Synonyms
            
			            		
			
			
            ARMETL1, ARMET-like protein 1, CDNF, cerebral dopamine neurotrophic factor
            
			            		
		
            
		
            
			
			
            Accession
            
			            		
			
			
            Q8CC36
            
			            		
		
            
		
            
			
			
            GeneID
            
			            		
			
			
            227526
            
			            		
		
            
		
            
			
			
            Source
            
			            		
			
			
            E.coli-derived rat CDNF protein, Gln25-Leu187.
            
			            		
		
            
		
            
			
			
            Molecular Weight
            
			            		
			
			
            Approximately 18.5 kDa.
            
			            		
		
            
		
            
			
			
            AA Sequence
            
			            		
			
			
            QGLEAGVGPR ADCEVCKEFL DRFYNSLLSR GIDFSADTIE KELLNFCSDA KGKENRLCYY LGATTDAATK ILGEVTRPMS VHIPAVKICE KLKKMDSQIC ELKYGKKLDL ASVDLWKMRV AELKQILQRW GEECRACAEK SDYVNLIREL APKYVEIYPQ TEL
            
			            		
		
            
		
            
			
			
            Tag
            
			            		
			
			
            None
            
			            		
		
            
		
            
			
			
            Physical Appearance
            
			            		
			
			
            Sterile Filtered White lyophilized (freeze-dried) powder.
            
			            		
		
            
		
            
			
			
            Purity
            
			            		
			
			
            >97% by SDS-PAGE and HPLC analyses.
            
			            		
		
            
		
            
			
			
            Biological Activity
            
			            		
			
			
            Fully biologically active when compared to standard. It is able to enhance neurite outgrowth of E16-E18 rat embryonic cortical neurons when immobilized at 5 - 30 µg/mL on a nitrocellulose-coated microplate.
            
			            		
		
            
		
            
			
			
            Endotoxin
            
			            		
			
			
            < 0.1 EU per 1μg of the protein by the LAL method.
            
			            		
		
            
		
            
			
			
            Formulation
            
			            		
			
			
            Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
            
			            		
		
            
		
            
			
			
            Reconstitution
            
			            		
			
			
            We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions.
            
			            		
		
            
	            

            


             
            


            Shipping and Storage
            


             
            


            The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.
            


            Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
            


             
            


            Cautions
            


            1. Avoid repeated freeze-thaw cycles.
            


            2. For your safety and health, please wear lab coats and disposable gloves for operation.
            


            3. For research use only!
            


             
            


            HB220418
            

               
             
                
             
             
             
             
             
             
            400-6111-883