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            Recombinant Human VCC-1/CXCL17
             
            更多活動(dòng)更多優(yōu)惠，盡在翌圣商城》
             
             
             
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            產(chǎn)品說明書
                  
            FAQ
                  
            COA
                  
            已發(fā)表文獻(xiàn)
                  
             
            CXCL17 also named dendritic cell and monocyte chemokine-like protein (DMC) and VEGF co-regulated chemokine 1 (VCC-1), is a small cytokine belonging to the CXC chemokine family. CXCL17 was the last chemokine ligand to be described and is the 17th member of the CXC chemokine family. Its strategic expression in mucosal tissues suggests that it is involved in innate immunity and/or sterility of the mucosa. Mature human DMC shares 73%, 71% and 64% amino acid sequence identity with bovine, mouse and rat DMC, respectively. It may be a housekeeping chemokine regulating recruitment of nonactivated blood monocytes and immature dendritic cells into tissues and may play a role in the innate defense against infections. CXCL17 also has a role in angiogenesis of importance for tumour development.
            


             
            


            Product Properties
            


            
	
		
            
			
			
            Synonyms
            
			            		
			
			
            C-X-C Motif Chemokine 17, CXCL17, Dcip1, DMC, UNQ473, VCC-1, VEGF Coregulated Chemokine 1, VEGF Co-Regulated Chemokine 1
            
			            		
		
            
		
            
			
			
            Accession
            
			            		
			
			
            Q6UXB2
            
			            		
		
            
		
            
			
			
            GeneID
            
			            		
			
			
            284340
            
			            		
		
            
		
            
			
			
            Source
            
			            		
			
			
            E.coli-derived human VCC-1/CXCL17 protein, Ser22-Leu119.
            
			            		
		
            
		
            
			
			
            Molecular Weight
            
			            		
			
			
            Approximately 11.5 kDa.
            
			            		
		
            
		
            
			
			
            AA Sequence
            
			            		
			
			
            SSLNPGVARG HRDRGQASRR WLQEGGQECE CKDWFLRAPR RKFMTVSGLP KKQCPCDHFK GNVKKTRHQR HHRKPNKHSR ACQQFLKQCQ LRSFALPL
            
			            		
		
            
		
            
			
			
            Tag
            
			            		
			
			
            None
            
			            		
		
            
		
            
			
			
            Physical Appearance
            
			            		
			
			
            Sterile Filtered White lyophilized (freeze-dried) powder.
            
			            		
		
            
		
            
			
			
            Purity
            
			            		
			
			
            >96% by SDS-PAGE and HPLC analyses.
            
			            		
		
            
		
            
			
			
            Biological Activity
            
			            		
			
			
            The ED50 as determined by its ability to induce VEGF expression using murine endothelial cells is less than 5.0 μg/ml, corresponding to a specific activity of > 200 IU/mg. Fully biologically active when compared to standard. 
            
			            		
		
            
		
            
			
			
            Endotoxin
            
			            		
			
			
            < 0.1 EU per 1μg of the protein by the LAL method.
            
			            		
		
            
		
            
			
			
            Formulation
            
			            		
			
			
            Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4, with 3 % Trehalose.
            
			            		
		
            
		
            
			
			
            Reconstitution
            
			            		
			
			
            We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions.
            
			            		
		
            
	            

            


             
            


            Shipping and Storage
            


            The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.
            


            Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
            


             
            


            Cautions
            


            1. Avoid repeated freeze-thaw cycles.
            


            2. For your safety and health, please wear lab coats and disposable gloves for operation.
            


            3. For research use only!
            


             
            


            HB220329
            

               
             
             
             
             
             
             
             
            400-6111-883