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            Recombinant Human GDF-7/BMP-12
             
            更多活動(dòng)更多優(yōu)惠，盡在翌圣商城》
             
             
             
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            產(chǎn)品說明書
                  
            FAQ
                  
            COA
                  
            已發(fā)表文獻(xiàn)
                  
             
            Growth Differentiation Factor-7 (GDF-7; also called BMP-12 and CDMP-3) is a member of the BMP family of TGF-beta superfamily proteins. GDF­7 is synthesized as a large precursor protein that consists of an N-­terminal 19 amino acid (aa) signal sequence, a 302 aa pro region and a 129 aa C-terminal mature peptide. At the amino acid level, mature human GDF-7 shares 85% and 88% aa sequence identity with mature GDF-7 in mouse and rat, respectively. Mature human GDF-7 lacks a glycine repeat that is found in both mouse and rat GDF-7. Based on sequence similarity, GDF-7 is categorized with GDF-5 and -6, as a subgroup within the BMP family. GDF-7 functions as a homodimer and elicits its bioactivity by mediating the formation of a heterodimeric receptor complex consisting of a type 1 (BMPR-IB) and a type II (BMPR-II or Activin RII) serine/threonine kinase receptor. GDF-7 signaling results in the phosphorylation and activation of cytosolic Smad proteins (Smad1, 5, and 8). 
            


             
            


            Product Properties
            


            
	
		
            
			
			
            Synonyms
            
			            		
			
			
            BMP12，GDF7
            
			            		
		
            
		
            
			
			
            Accession
            
			            		
			
			
            Q7Z4P5
            
			            		
		
            
		
            
			
			
            GeneID
            
			            		
			
			
            151449
            
			            		
		
            
		
            
			
			
            Source
            
			            		
			
			
            E.coli-derived Human GDF-7/BMP-12, Thr322-Arg450.
            
			            		
		
            
		
            
			
			
            Molecular Weight
            
			            		
			
			
            Approximately 28.0 kDa.
            
			            		
		
            
		
            
			
			
            AA Sequence
            
			            		
			
			
            TALAGTRTAQ GSGGGAGRGH GRRGRSRCSR KPLHVDFKEL GWDDWIIAPL DYEAYHCEGL CDFPLRSHLE PTNHAIIQTL LNSMAPDAAP ASCCVPARLS PISILYIDAA NNVVYKQYED MVVEACGCR
            
			            		
		
            
		
            
			
			
            Tag
            
			            		
			
			
            None
            
			            		
		
            
		
            
			
			
            Physical Appearance
            
			            		
			
			
            Sterile Filtered White lyophilized (freeze-dried) powder.
            
			            		
		
            
		
            
			
			
            Purity
            
			            		
			
			
            > 95% by SDS-PAGE and HPLC analyses.
            
			            		
		
            
		
            
			
			
            Biological Activity
            
			            		
			
			
             The ED50 as determined by inducing alkaline phosphatase production of murine ATDC5 cells is less than 1.0 μg/mL, corresponding to a specific activity of > 1000 IU/mg. Fully biologically active when compared to standard. 
            
			            		
		
            
		
            
			
			
            Endotoxin
            
			            		
			
			
            < 0.1 EU per 1μg of the protein by the LAL method.
            
			            		
		
            
		
            
			
			
            Formulation
            
			            		
			
			
            Lyophilized from a 0.2 µm filtered concentrated solution in 30% Acetonitrile and 0.1% TFA.
            
			            		
		
            
		
            
			
			
            Reconstitution
            
			            		
			
			
            We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions.
            
			            		
		
            
	            

            


             
            


            Shipping and Storage
            


            The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.
            


            Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
            


             
            


            Cautions
            


            1. Avoid repeated freeze-thaw cycles.
            


            2. For your safety and health, please wear lab coats and disposable gloves for operation.
            


            3. For research use only!
            


             
            


            HB220318
            


             
            

               
             
             
             
             
             
             
             
            400-6111-883