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            Recombinant Human IL-22 Protein重組人白介素22
             
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            產(chǎn)品說明書
                  
            FAQ
                  
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            Interleukin-22 (IL-22), also known as IL-10-related T cell-derived inducible factor (IL-TIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. Human IL-22 cDNA encodes a 179 amino acid (aa) residue protein with a putative 33 aa signal peptide that is cleaved to generate a 147 aa mature protein that shares approximately 79% and 22% aa sequence identity with mouse IL-22 and human IL-10, respectively. The human IL-22 gene is localized to chromosome 12q15. Although it exists as a single copy gene in human and in many mouse strains, the mouse IL-22 gene is duplicated in some mouse strains including C57B1/6, FVB and 129. The two mouse genes designated IL-TIF alpha and IL-TIF beta, share greater than 98% sequence homology in their coding region. IL-22 has been shown to activate STAT1 and STAT-3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R (previously an orphan receptor named CRF2-9) and IL-10R beta (previously known as CRF2-4), belonging to the class II cytokine receptor family.
            


             
            


            Product Properties
            


            
	
		
            
			
			
            Synonyms
            
			            		
			
			
            Cytokine Zcyto 18, TIF
            
			            		
		
            
		
            
			
			
            Accession
            
			            		
			
			
            Q9GZX6
            
			            		
		
            
		
            
			
			
            GeneID
            
			            		
			
			
            50616
            
			            		
		
            
		
            
			
			
            Source
            
			            		
			
			
            E.coli-derived human IL-22 protein,Ala34-Ile179.
            
			            		
		
            
		
            
			
			
            Molecular Weight
            
			            		
			
			
            Approximately 33.6 kDa.
            
			            		
		
            
		
            
			
			
            AA Sequence
            
			            		
			
			
            MAPISSHCRL DKSNFQQPYI TNRTFMLAKE ASLADNNTDV RLIGEKLFHG VSMSERCYLM KQVLNFTLEE VLFPQSDRFQ PYMQEVVPFL ARLSNRLSTC HIEGDDLHIQ RNVQKLKDTV KKLGESGEIK AIGELDLLFM SLRNACI
            
			            		
		
            
		
            
			
			
            Tag
            
			            		
			
			
            None
            
			            		
		
            
		
            
			
			
            Physical Appearance
            
			            		
			
			
            Sterile Filtered White lyophilized (freeze-dried) powder.
            
			            		
		
            
		
            
			
			
            Purity
            
			            		
			
			
            > 97% by SDS-PAGE and HPLC analyses.
            
			            		
		
            
		
            
			
			
            Biological Activity
            
			            		
			
			
            Fully biologically active when compared to standard. The ED50 as determined by inducing IL-10 secretion of human COLO 205 cells is less than 0.3 ng/ml, corresponding to a specific activity of > 3.3 × 106 IU/mg.
            
			            		
		
            
		
            
			
			
            Endotoxin
            
			            		
			
			
            < 1.0 EU per 1μg of the protein by the LAL method.
            
			            		
		
            
		
            
			
			
            Formulation
            
			            		
			
			
            Lyophilized from a 0.2 µm filtered concentrated solution in PBS, pH 5.0.
            
			            		
		
            
		
            
			
			
            Reconstitution
            
			            		
			
			
            We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20°C. Further dilutions should be made in appropriate buffered solutions.
            
			            		
		
            
	            

            


             
            

            


            Shipping and Storage
            


            The products are shipped with ice pack and can be stored at -20℃ for 1 year.
            


            1 month, 2 to 8 °C under sterile conditions after reconstitution.
            


            3 months, -20 °C under sterile conditions after reconstitution.
            


            Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
            


             
            


            Cautions
            


            1.Avoid repeated freeze-thaw cycles.
            


            2.For your safety and health, please wear lab coats and disposable gloves for operation.
            


            3.For research use only.
            


            HB221018
            


             
            

               
             
             
             
             
             
             
             
            400-6111-883