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            Recombinant Human BCA-1/CXCL13
             
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            產(chǎn)品說明書
                  
            FAQ
                  
            COA
                  
            已發(fā)表文獻(xiàn)
                  
             
            The homeostatic chemokine CXCL13 (also called B cell-attracting chemokine 1 [BCA-1] or B-lymphocyte chemoattractant [BLC]) is constitutively expressed in secondary lymphoid tissue and initiates lymphoid neogenesis when expressed aberrantly. Recombinant human CXCL13 is a single non-glycosylated polypeptide chain containing 87 amino acids and mature human BCA-1 shares 64% amino acid sequence similarity with the mouse protein and 23-34% amino acid sequence identity with other known CXC chemokines. CXCL13 is a homeostatic chemokine for lymphocyte homing and positioning within follicles of secondary lymphoid tissues, acting through its cognate receptor, CXCR5. Besides, CXCL13 is a potent chemokine, produced by mature and recently recruited macrophages to sites of inflammation, which has antimicrobial and anti-angiogenic properties.
            


             
            


            Product Properties
            


            
	
		
            
			
			
            Synonyms
            
			            		
			
			
            Angie, B lymphocyte chemoattractant, BCA1, CXC chemokine BLC, Small-inducible cytokine B13,  SCYB13
            
			            		
		
            
		
            
			
			
            Accession
            
			            		
			
			
            O43927
            
			            		
		
            
		
            
			
			
            GeneID
            
			            		
			
			
            10563
            
			            		
		
            
		
            
			
			
            Source
            
			            		
			
			
            E.coli-derived Human BCA-1/CXCL13, Val23-Pro109.
            
			            		
		
            
		
            
			
			
            Molecular Weight
            
			            		
			
			
            Approximately 10.3 kDa.
            
			            		
		
            
		
            
			
			
            AA Sequence
            
			            		
			
			
            VLEVYYTSLR CRCVQESSVF IPRRFIDRIQ ILPRGNGCPR KEIIVWKKNK SIVCVDPQAE WIQRMMEVLR KRSSSTLPVP VFKRKIP
            
			            		
		
            
		
            
			
			
            Tag
            
			            		
			
			
            None
            
			            		
		
            
		
            
			
			
            Physical Appearance
            
			            		
			
			
            Sterile Filtered White lyophilized (freeze-dried) powder.
            
			            		
		
            
		
            
			
			
            Purity
            
			            		
			
			
            > 97% by SDS-PAGE and HPLC analyses.
            
			            		
		
            
		
            
			
			
            Biological Activity
            
			            		
			
			
            The biological activity determined by a chemotaxis bioassay using human B cells is in a concentration range of 1.0-10 ng/mL. Fully biologically active when compared to standard. 
            
			            		
		
            
		
            
			
			
            Endotoxin
            
			            		
			
			
            < 1.0 EU per 1μg of the protein by the LAL method.
            
			            		
		
            
		
            
			
			
            Formulation
            
			            		
			
			
            Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, pH 7.4, 100 mM NaCl.
            
			            		
		
            
		
            
			
			
            Reconstitution
            
			            		
			
			
            We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions.
            
			            		
		
            
	            

            


             
            


            Shipping and Storage
            


            The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.
            


            Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
            


             
            


            Cautions
            


            1. Avoid repeated freeze-thaw cycles.
            


            2. For your safety and health, please wear lab coats and disposable gloves for operation.
            


            3. For research use only!
            


             
            


            HB220215
            

               
             
             
             
             
             
             
             
            400-6111-883