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            Recombinant Mouse GM-CSF Protein重組小鼠粒細胞巨噬細胞集落刺激因子
             
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            產(chǎn)品說明書
                  
            FAQ
                  
            COA
                  
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            Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) is a powerful growth and differentiation factor which acts on hematopoietic progenitor cells and also activates differentiated granulocytes and macrophages. The 22 kDa glycosylated GMCSF, similar to IL3 and IL5, is a cytokine with a core of four bundled alpha -helices. Mature human GMCSF shares 63%70% amino acid sequence identity with canine, feline, porcine, and rat GMCSF and 54% with mouse GMCSF. GM-CSF has been and is still widely used as an adjuvant in clinical trials of vaccination with autologous tumor cells, peptides and/or dendritic cells in a variety of human neoplasms. The effects of GM-CSF on HIV-1 replication in primary monocytes and macrophages, and in related cell lines, have demonstrated augmentation of HIV-1 expression in vitro.
            


             
            


            Product Properties
            


            
	
		
            
			
			
            Synonyms
            
			            		
			
			
            Granulocyte/Macrophage Colony-Stimulating Factor, GM-CSF, CSF-2, MGI-1GM, Pluripoietin-α
            
			            		
		
            
		
            
			
			
            Accession
            
			            		
			
			
            P01587
            
			            		
		
            
		
            
			
			
            GeneID
            
			            		
			
			
            12981
            
			            		
		
            
		
            
			
			
            Source
            
			            		
			
			
            E.coli-derived mouse GM-CSF protein, Ala18-Lys141.
            
			            		
		
            
		
            
			
			
            Molecular Weight
            
			            		
			
			
            Approximately 14.1 kDa.
            
			            		
		
            
		
            
			
			
            AA Sequence
            
			            		
			
			
            APTRSPITVT RPWKHVEAIK EALNLLDDMP VTLNEEVEVV SNEFSFKKLT CVQTRLKIFE QGLRGNFTKL KGALNMTASY YQTYCPPTPE TDCETQVTTY ADFIDSLKTF LTDIPFECKK PGQK
            
			            		
		
            
		
            
			
			
            Tag
            
			            		
			
			
            None
            
			            		
		
            
		
            
			
			
            Physical Appearance
            
			            		
			
			
            Sterile Filtered White lyophilized (freeze-dried) powder.
            
			            		
		
            
		
            
			
			
            Purity
            
			            		
			
			
            > 98% by SDS-PAGE and HPLC analyses.
            
			            		
		
            
		
            
			
			
            Biological Activity
            
			            		
			
			
            The ED50 as determined by a cell proliferation assay using murine FDC-P1 cells is less than 0.05 ng/mL, corresponding to a specific activity of > 2.0 × 107 IU/mg. Fully biologically active when compared to standard. 
            
			            		
		
            
		
            
			
			
            Endotoxin
            
			            		
			
			
            < 1.0 EU per 1μg of the protein by the LAL method.
            
			            		
		
            
		
            
			
			
            Formulation
            
			            		
			
			
            Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4. 
            
			            		
		
            
		
            
			
			
            Reconstitution
            
			            		
			
			
            We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20°C. Further dilutions should be made in appropriate buffered solutions.
            
			            		
		
            
	            

            


             
            

            


            Shipping and Storage
            


            The products are shipped with ice pack and can be stored at -20 ℃ for 1 year.
            


            1 month, 2 to 8 °C under sterile conditions after reconstitution.
            


            3 months, -20 °C under sterile conditions after reconstitution.
            


            Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
            


             
            


            Cautions
            


            1.Avoid repeated freeze-thaw cycles.
            


            2.For your safety and health, please wear lab coats and disposable gloves for operation.
            


            3.For research use only.
            


            HB221018
            

               
             
             
             
             
             
             
             
            400-6111-883